General socio-demographic and obstetric characteristics of the pregnant women studied are shown in Table?1. were calculated by multivariate analysis using the Enter method. A value less KD 5170 than 0.05 was considered statistically significant. Results In total, we enrolled 343 pregnant women. Most of them were born in Durango; their mean age was 28.88??6.12?years (range 15C43 years). General socio-demographic and obstetric characteristics of the pregnant women studied are shown in Table?1. Anti-CMV IgG antibodies were detected in 225 (65.6%) of the 343 pregnant women studied. None of the 343 pregnant women had anti-CMV IgM antibodies. KD 5170 Table 1 Socio-demographic and obstetric characteristics of pregnant women and seroprevalence of CMV infection value 0.10 by bivariate analysis. Other socio-demographic characteristics including birthplace, residence, educational level, occupation and socio-economic status had values 0.10 by bivariate analysis. With respect to behavioral characteristics, smoking was the only variable that showed a value 0.10 by bivariate analysis. Other behavioral characteristics including foreign travel, eating away of home, consumption of untreated water, and unwashed raw vegetables or fruits, drug or alcohol addictions, sexual promiscuity, washing hands before eating, and type of flooring at home show values 0.10 by bivariate analysis. Concerning clinical characteristics, seroprevalence of CMV infection was similar in ill (7/15: 46.7%) than in healthy (217/327: 66.4%) pregnant women (values equal to or lower than 0.10 by bivariate analysis (Table?2) showed that CMV infection was positively associated only with age (OR?=?1.67; 95% CI: 1.01-2.76; em P /em ?=?0.04). Table 2 Multivariate analysis of selected characteristics of pregnant women and their association with CMV infection thead th rowspan=”1″ colspan=”1″ Characteristic /th th align=”center” rowspan=”1″ colspan=”1″ Odds ratioa /th th align=”center” rowspan=”1″ colspan=”1″ 95%confidence interval /th th align=”center” rowspan=”1″ colspan=”1″ em P /em value /th /thead Age (31C43 years)1.671.01 – 2.760.04Lymphadenopathy2.030.98 – 4.190.05More than 2 pregnancies1.360.81 – 2.260.23Smoking0.530.26 – 1.070.08 Open in a separate window aAdjusted by the characteristics included in this Table. Discussion There is a lack of knowledge about the epidemiology of CMV infection in pregnant women in Mexico. The present study was performed to investigate the seroprevalence and correlates of CMV infection in pregnant women in the northern Mexican city of Durango. We found a 65.6% seroprevalence of CMV infection in the pregnant women studied. Based on the seropositivity to CMV IgG and IgM antibodies, all women with CMV exposure had Mouse monoclonal antibody to eEF2. This gene encodes a member of the GTP-binding translation elongation factor family. Thisprotein is an essential factor for protein synthesis. It promotes the GTP-dependent translocationof the nascent protein chain from the A-site to the P-site of the ribosome. This protein iscompletely inactivated by EF-2 kinase phosporylation latent infection and none had recent or acute CMV infection. We are not aware of previous reports about the seroepidemiology of CMV infection in pregnant women in Mexico. Therefore, we cannot compare our seroprevalence results with others in pregnant women in Mexico. In a study in healthy women of reproductive age in Cuernavaca City in central Mexico, researchers found a 92.6% seroprevalence of CMV infection [12]. While in a national survey in subjects KD 5170 aged 1 to 70?years old in Mexico an 88.2% seroprevalence of CMV infection was found [11]. On the other hand, comparison of our seroprevalence with those reported in other countries suggests that the seroprevalence of CMV infection in pregnant women in Durango could be placed in an intermediate position of endemicity. The 65.6% seroprevalence found in pregnant women in Durango is similar to the 62.4%-66% seroprevalences reported in pregnant women in Poland [13], Japan [14], and Norway [15], and higher than the 49% seroprevalence in white British pregnant women in the United Kingdom [16] and a 42.3% seroprevalence in pregnant women in Germany [17]. In contrast, the seroprevalence found in pregnant women in Durango is lower than the 92.6%-100% seroprevalences reported in pregnant women in Iran [18], Palestine [19], Brazil [20], Turkey [21], Nigeria [22], and Cuba [23]. Analysis of the socio-demographic characteristics showed that the seroprevalence of CMV infection in pregnant women increased with age. This finding is consistent with those reported in other studies where researchers found an KD 5170 increase KD 5170 in the seroprevalence of CMV infection with age in both pregnant women [13] and general population [24]. Other known contributing factors for CMV infection including socioeconomic status [8], education, sexual promiscuity [12], blood transfusion and transplantation [25] did not show any association with CMV exposure in the women studied. Of the sources of infection with CMV in pregnant women stands out young children [26, 27]. We assess the contact with young children by evaluating the number of children the women have already born (history of pregnancies), considering that women with more than two pregnancies had a higher contact with children than women with fewer pregnancies. Analysis showed that women with more than two pregnancies had a higher,.
