The D661Y mutation is recurrent in T/NK-cell neoplasms and was previously shown to be associated with both STAT3 constitutive phosphorylation and increased transcriptional activity

The D661Y mutation is recurrent in T/NK-cell neoplasms and was previously shown to be associated with both STAT3 constitutive phosphorylation and increased transcriptional activity.23 Indeed, western blot analysis confirmed basal STAT3 phosphorylation in this cell line, which was abrogated on enforced expression of exogenous SOCS1 (supplemental Figure 8). Open in a separate window Figure 4. …
Continue reading The D661Y mutation is recurrent in T/NK-cell neoplasms and was previously shown to be associated with both STAT3 constitutive phosphorylation and increased transcriptional activity