Canonical Wnt and mTOR pathways can be negatively regulated by the serine/threonine kinase GSK3 [31C33]. and its Supporting Information files. Abstract Tyrosine kinase inhibitors (TKIs) against EGFR and c-Met are initially effective when administered individually or in combination to non-small cell lung cancer (NSCLC) patients. However, the overall efficacies of TKIs are limited due to …
Continue reading Canonical Wnt and mTOR pathways can be negatively regulated by the serine/threonine kinase GSK3 [31C33]
Category:Src Kinase
The lysates were subjected to immunoprecipitation with GFP-Trap beads
The lysates were subjected to immunoprecipitation with GFP-Trap beads. a novel bad feedback on mTORC1. Our findings uncover ZNRF2 as a component of the amino acid sensing machinery that functions upstream of Rag-GTPases and the V-ATPase to activate mTORC1. DOI: http://dx.doi.org/10.7554/eLife.12278.001 PAT1 (proton-assisted transporter 1) (Bar-Peled and Sabatini, 2014; Bar-Peled et al., 2012; Nada et …
Continue reading The lysates were subjected to immunoprecipitation with GFP-Trap beads