F6 was most reliable at killing GSCs, while MG18L was similar to G47, except in GBM8 (Fig 3A)

F6 was most reliable at killing GSCs, while MG18L was similar to G47, except in GBM8 (Fig 3A). determined using Chou-Talalay analysis. efficacy studies were performed using a clinically relevant mouse model of GSC-derived glioblastoma. Results MG18L was severely neuroattenuated in mice, replicated well in GSCs, and had anti-glioblastoma activity against a number of cancer …
Continue reading F6 was most reliable at killing GSCs, while MG18L was similar to G47, except in GBM8 (Fig 3A)

[4] suggested that the capability of internalized CTXs to disrupt lysosome determines their cytotoxicity in human lung cancer A549 cells and leukemia HL60 cells

[4] suggested that the capability of internalized CTXs to disrupt lysosome determines their cytotoxicity in human lung cancer A549 cells and leukemia HL60 cells. AMPK. Overexpression of PP2Ac mitigated the CTX3-induced AMPK phosphorylation. CTX3-induced autophagy was via AMPK-mediated suppression of the Akt/mTOR pathway. Removal of Ca2+ or suppression of AMPK phosphorylation inhibited the CTX3-induced cell …
Continue reading [4] suggested that the capability of internalized CTXs to disrupt lysosome determines their cytotoxicity in human lung cancer A549 cells and leukemia HL60 cells