´╗┐Several experimental studies indicate that binding to the inner pore of the channel results in the pharmacologic block of hERG1 [14], [15], while binding to the site in the S4CS5 linker appears to contribute substantially to channel activation [7]

´╗┐Several experimental studies indicate that binding to the inner pore of the channel results in the pharmacologic block of hERG1 [14], [15], while binding to the site in the S4CS5 linker appears to contribute substantially to channel activation [7]. data are within the paper and its Supporting Information documents. Abstract One of the main culprits …
Continue reading ´╗┐Several experimental studies indicate that binding to the inner pore of the channel results in the pharmacologic block of hERG1 [14], [15], while binding to the site in the S4CS5 linker appears to contribute substantially to channel activation [7]